Isolated Mouse Pancreatic Islets
نویسندگان
چکیده
Inosine is a potent primary stimulus of insulin secretion from isolated mouse islets. The inosine-induced insulin secretion was totally depressed during starvation, but was completely restored by the addition of 5mmi-caffeine to the medium and partially restored by the addition of 5mM-glucose. Mannoheptulose (3mg/ml) potentiated the eflect of lOmM-inosine in islets from fed mice. The mechanism of the stimulatory effect of inosine was further investigated, and it was demonstrated that pancreatic islets contain
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